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Laboratory study reveals presenilins Psen1 and Psen2 maintain intestinal homoeostasis, highlighting an unexpected non-neural role.
Mutations in presenilin genes are the major cause of Alzheimer's disease. However, little is known about their expression and function in the gut. In this study, we identify the presenilins Psen1 and Psen2 as key molecules that maintain intestinal homoeostasis.
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Erkert et al. (2024) studied this question.
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