April 29, 2024PLoS PathogensOpen Access

CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection

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Authors

CFCintia L. Araujo FurlanConsejo Nacional de Investigaciones Científicas y Técnicas SBSantiago BoccardoConsejo Nacional de Investigaciones Científicas y Técnicas CRConstanza RodríguezNational Institutes of Health

Discussion

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Implication

Experimental study reveals CD39 on regulatory T cells suppresses CD8+ T cell immunity during acute Trypanosoma cruzi infection in mice, suggesting an immunomodulatory target.

Key Points

Regulatory Foxp3+ T cells suppress protective parasite-specific CD8+ T cell responses during acute Trypanosoma cruzi infection, impairing early parasite control.
In the DEREG mouse model, early regulatory T cell depletion increased polyfunctional effector T cell subsets and boosted anti-parasite CD4+ T cell responses.
Findings highlight that CD39 expression on regulatory T cells mediates effector CD8+ T cell suppression — mouse model; further preclinical validation needed.

Cite This Study

Furlan et al. (2024) studied this question.

synapsesocial.com/papers/68e6d05eb6db64358764e15a https://doi.org/10.1371/journal.ppat.1012191

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Implication

Experimental study reveals CD39 on regulatory T cells suppresses CD8+ T cell immunity during acute Trypanosoma cruzi infection in mice, suggesting an immunomodulatory target.

CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection

Discussion

Member takes

Implication

Key Points

Cite This Study

CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection

Discussion

Member takes

Implication

Key Points

Cite This Study

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