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November 1, 2025Open Access

Trypanosoma cruzi Infection Activates Transgenic DO11.10 CD4+ T Cells

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Cytometry reveals Trypanosoma cruzi activates Foxp3+ T cells and alters cytokine response in chronic infections, suggesting immune implications.

Trypanosoma cruzi activation of transgenic CD4+ T cells leads to significant immune responses against the parasite.
Cytometry identifies mixed cytokine production, particularly IFN-γ and IL-10, in this process.
The study underscores the importance of TCR cross-reactivity, impacting the immune landscape during chronic infection.
Foxp3 expression in transgenic T cells highlights potential autoimmunity risks linked to persistent infections.

Cardillo et al. (2025) studied this question.

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Cytometry reveals Trypanosoma cruzi activates Foxp3+ T cells and alters cytokine response in chronic infections, suggesting immune implications.