Key result
CD4+ cytotoxic T cells abundantly differentiate during T. cruzi infection via T-cell intrinsic IL-18R/MyD88 signaling, and their frequency correlates with cardiomyopathy severity in Chagas patients.
Population
Mice infected with Trypanosoma cruzi (WT, Myd88-/-, Il18ra-/-) and human Chagas patients
Comparison
T-cell intrinsic IL-18R/MyD88 signaling vs Myd88-/- and Il18ra-/- mice/cells
Design
Preclinical
Authors
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May inform CD4CTL roles in Chagas cardiomyopathy; leaves open therapeutic targeting pending human validation.
T-cell intrinsic IL-18R/MyD88 signaling is a key pathway controlling the CD4CTL response, which plays a major role in immunity to Trypanosoma cruzi and correlates with Chagas cardiomyopathy severity.
Barbosa et al. (2022) studied Trypanosoma cruzi infection / Chagas disease. T-cell intrinsic IL-18R/MyD88 signaling vs. Wild-type vs Myd88-/- and Il18ra-/- was evaluated on CD4CTL differentiation, cytotoxicity, and correlation with cardiomyopathy severity. CD4+ cytotoxic T cells abundantly differentiate during T. cruzi infection via T-cell intrinsic IL-18R/MyD88 signaling, and their frequency correlates with cardiomyopathy severity in Chagas patients.
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