Population
Chronically Trypanosoma cruzi-infected mice, fetal heart clusters, and BALB/c nude mice
Design
Preclinical
Authors
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Supports autoimmune mechanism in Chagas cardiomyopathy; animal data leave open human translation and therapies.
Demonstrates that autoreactive CD4+ T cells can induce carditis and heart transplant rejection in the absence of T. cruzi, supporting an autoimmune mechanism in Chagas cardiomyopathy.
Ribeiro‐dos‐Santos et al. (2001) studied this question.
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