Key result
Persistent infection with Trypanosoma cruzi leads to the upregulation of inhibitory receptors CTLA-4 and LIR-1 on parasite-specific T cells and in heart tissues of subjects with severe myocarditis.
Population
Subjects chronically infected with Trypanosoma cruzi with different clinical forms of the disease, heart…
Comparison
In vitro ligation of CTLA-4 and LIR-1, CTLA-4… vs Uninfected individuals, and baseline vs…
Design
Cross-sectional
Authors
Loading...
Should not yet change Chagas myocarditis management; hypothesis-generating for T-cell exhaustion and inhibitory receptor targeting.
Observational (n=107)
Persistent T. cruzi infection leads to upregulation of inhibitory receptors like CTLA-4 and LIR-1 on T cells, contributing to T cell exhaustion in chronic Chagas disease and severe myocarditis.
Argüello et al. (2012) conducted an observational in Chronic Chagas Disease (n=107). Chronic Trypanosoma cruzi infection vs. Uninfected subjects was evaluated on Expression of CTLA-4 and LIR-1 by peripheral T. cruzi antigen-responsive IFN-gamma-producing T cells. Persistent infection with Trypanosoma cruzi leads to the upregulation of inhibitory receptors CTLA-4 and LIR-1 on parasite-specific T cells and in heart tissues of subjects with severe myocarditis.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: