A Pd(II)-catalyzed tandem reaction of aliphatic amides with vinylcyclopropanes (VCPs) was accomplished by merging C(sp3)–H and C–C activation. The reaction of VCP revealed alkenylation/cyclization, followed by ring opening via C–C cleavage, delivering vinyl γ-lactams with (E)-selectivity. The role of ligands, site-selectivity, functional group diversity, mechanistic insight, and synthetic utilities are important practical features.
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Barman et al. (2024) studied this question.
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