Experimental study demonstrates Pd(II)-catalyzed intramolecular amination of unactivated bonds, suggesting a streamlined pathway to diverse β-, γ-, and δ-lactam rings.
Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams.
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Wasa et al. (2008) studied this question.
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