Herein, we report a Pd‐catalyzed aerobic lactamization of unactivated γ ‐C( sp 3 )−H bonds of aliphatic carboxylic acids and amino acids derivatives. The utilization of Pd(OAc) 2 as a catalyst, along with catalytic AgNO 2 as an electron transfer mediator, circumvents the need for stoichiometric oxidants and demonstrates significant practicality.
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Jia et al. (2024) studied this question.
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