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April 26, 2024CancersOpen Access

Genomic Characterization of Partial Tandem Duplication Involving the KMT2A Gene in Adult Acute Myeloid Leukemia

Andrew Seto Gregory S. Downs Olivia King Shabnam Salehi‐Rad Ana Alice Baptista Kayu Chin Sylvie Grenier Bevoline Nwachukwu Anne Tierens Mark D. Minden Adam C. Smith José‐Mario Capo‐Chichi

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Key Points

Partial tandem duplication involving the KMT2A gene defines distinct genomic alterations and structural gene rearrangements in adult acute myeloid leukemia.
Genomic characterization evaluates partial tandem duplication architecture across the KMT2A gene locus, delineating specific gene rearrangements in leukemia.
Identification of KMT2A partial tandem duplication supports refined genomic characterization of adult acute myeloid leukemia and its associated gene rearrangements.

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Implication

Genomic analysis reveals partial tandem duplication of the KMT2A gene in adult acute myeloid leukemia, highlighting structural gene rearrangements.

Abstract

Gene rearrangements affecting

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Cite This Study

Seto et al. (2024) studied this question.

synapsesocial.com/papers/68e6d598b6db643587652fb6 https://doi.org/10.3390/cancers16091693

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