Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration.

The treatment of dermatological diseases has evolved significantly with the advent of advanced therapeutic strategies involving platelet-rich products. These products are rich in morphogens, growth factors, and proteins that play a crucial role in tissue regeneration and wound healing. Their combination with different biomaterials has been engineered to enhance the biomaterials' safety and performance in the context of tissue healing. This narrative review aims to explore the current evidence on the biological mechanisms, efficacy, and clinical applications of these combined therapies. Furthermore, we examine the potential advantages of synergistic effects and the challenges associated with optimizing treatment protocols. Relevant literature was retrieved through a structured search strategy implemented across PubMed, Scopus, and Google Scholar databases. Studies included investigated co-administration of platelet-rich products with other agents in topical, injectable, or composite formulations for dermatological conditions with no restriction regarding publication date. The review summarizes in vitro and in vivo biological effects of various biopolymers and active substances combined with platelet-rich products, highlighting diverse application strategies and their effectiveness across dermatological contexts. Adding platelet-rich products has shown promising results in enhancing therapeutic outcomes for various dermatological conditions, including chronic wounds, burns, scars, and skin aging. Although promising results have been reported, the need for critical thinking regarding the selection of the biomaterial and the platelet-rich products, standardized methodologies, large-scale randomized controlled trials, and long-term follow-up studies is emphasized to fully establish the clinical benefits of these combined treatments in dermatology.