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December 3, 2025Journal of Clinical MedicineOpen Access

Platelet-Rich Plasma (PRP) and Recombinant Growth Factor Therapies in Cutaneous Wound Healing: Mechanisms, Clinical Applications, and Future Directions

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Authors

AAAbu-Bakr AhmedUniversity of Nevada, Las VegasSTSpencer ThatcherUniversity of Nevada, Las VegasJKJoshua KhorsandiUniversity of Nevada, Las Vegas

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Implication

Narrative review demonstrates enhanced wound closure in diabetic foot ulcers and pressure injuries, suggesting biologic therapies may optimize treatment outcomes.

Key Points

  • Complete wound closure improves by 2–8 times in chronic ulcers with PRP compared to standard care.
  • Randomized controlled trials report positive healing rates in diabetic foot ulcers with specific growth factors.
  • Observational analysis reveals reduced healing times in burns treated with EGF and bFGF.
  • Standardized trials on cytokine composition and long-term benefits are needed for routine clinical integration.

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/694025972d562116f28fea43https://doi.org/10.3390/jcm14238583
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Artificial Intelligence Methods for Diagnostic and Decision-Making Assistance in Chronic Wounds: A Systematic Review2025 · 50 citations
  2. 2The Japanese Experience with Basic Fibroblast Growth Factor in Cutaneous Wound Management and Scar Prevention: A Systematic Review of Clinical and Biological Aspects2020 · 58 citations
  3. 3Prevention and treatment of pressure ulcers/injuries: The protocol for the second update of the international Clinical Practice Guideline 20192019 · 439 citations
  4. 4Use of Becaplermin for nondiabetic ulcers: pyoderma gangrenosum and calciphylaxis2015 · 13 citations
  5. 5The application of platelet‐rich plasma in the treatment of deep dermal burns: A randomized, double‐blind, intra‐patient controlled study2016 · 76 citations