Platelet-Rich Plasma for Burn Wound Healing in Preclinical Models: A Systematic Review of Efficacy and Biomolecular Mechanisms

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Systematic review evaluates platelet-rich plasma's effects on wound healing in burn injuries, indicating potential benefits but high bias risk.

PRP shows potential to enhance burn wound healing based on evidence from eleven studies involving 526 animals.
Macroscopically, PRP accelerates wound closure in partial-thickness burns within 4-7 days and in full-thickness from day 8.
Biomolecularly, PRP increases fibroblast scores and elevates VEGF and EGF levels significantly post-treatment.
High risk of bias and methodological differences across studies limit definitive conclusions about PRP's efficacy.

Whandyra et al. (2025) studied this question.

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View Full Paper

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Authors

Systematic review evaluates platelet-rich plasma's effects on wound healing in burn injuries, indicating potential benefits but high bias risk.

PRP shows potential to enhance burn wound healing based on evidence from eleven studies involving 526 animals.
Macroscopically, PRP accelerates wound closure in partial-thickness burns within 4-7 days and in full-thickness from day 8.
Biomolecularly, PRP increases fibroblast scores and elevates VEGF and EGF levels significantly post-treatment.
High risk of bias and methodological differences across studies limit definitive conclusions about PRP's efficacy.

Whandyra et al. (2025) studied this question.

View Full Paper

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Bookmark