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Cross-sectional analysis finds high sdLDL-C correlates with elevated IMA in hyperlipidemic patients, indicating cardiovascular risk.
Background: Small dense low-density lipoprotein cholesterol (sdLDL-C) is recognized as a highly atherogenic lipoprotein subfraction implicated in cardiovascular risk. Ischemia-modified albumin (IMA) serves as a biomarker of oxidative stress and ischemic conditions. Both markers are important in understanding the pathophysiology of hyperlipidemia-related cardiovascular diseases. Objective: This study investigates the relationship between sdLDL-C levels and IMA concentrations in patients with hyperlipidemia to elucidate potential synergistic roles in cardiovascular risk stratification. Methods: A cross-sectional analysis was conducted on hyperlipidemic patients attending a tertiary care center. Serum sdLDL-C and IMA levels were measured and correlated with lipid profiles and clinical parameters. Statistical analyses evaluated the strength and significance of associations. Results: Elevated sdLDL-C levels showed a significant positive correlation with increased IMA concentrations, indicating heightened oxidative stress in hyperlipidemic patients. This association suggests that combined measurement of sdLDL-C and IMA could improve early detection of vascular ischemia and risk assessment. Conclusion: The findings support a close link between atherogenic lipoprotein subfractions and ischemia-related oxidative modifications in hyperlipidemia. Integrating sdLDL-C and IMA assessments may enhance cardiovascular risk prediction and guide therapeutic interventions.
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Mendoza et al. (2025) studied this question.
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