April 24, 2024Angewandte Chemie International Edition

Bioorthogonal Cu Single‐atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis, and Immunotherapy

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Authors

LWLuyan WuNanjing University of Posts and Telecommunications HLHuihui LinAgency for Science, Technology and Research XCXiang CaoNanjing University of Posts and Telecommunications

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Implication

Experimental study demonstrates ultrafast synthesis of copper single-atom nanozymes, suggesting therapeutic utility across nanocatalytic therapy and immunotherapy.

Key Points

Planar copper single-atom nanozymes enable multimodal antitumor activity, linking cuproptosis and nanocatalytic therapy to induce potent synergistic tumor ablation.
Fabrication using an ultrafast in situ bombarding-embedding technique successfully produces single-atom nanozymes with unique planar copper coordination motifs.
Supports the design of multifunctional bioorthogonal catalysts for photothermal therapy and immunotherapy, though in vivo validation remains necessary for clinical translation.

Cite This Study

Wu et al. (2024) studied this question.

synapsesocial.com/papers/68e6dc0eb6db643587657d6c https://doi.org/10.1002/anie.202405937

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Implication

Experimental study demonstrates ultrafast synthesis of copper single-atom nanozymes, suggesting therapeutic utility across nanocatalytic therapy and immunotherapy.

Bioorthogonal Cu Single‐atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis, and Immunotherapy

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Implication

Key Points

Cite This Study

Bioorthogonal Cu Single‐atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis, and Immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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