Introduction 3D-bioprinted preclinical tumour model enables the fabrication of spatially defined tumour microenvironment (TME) mimicking the in-vivo situation. It is challenging to opt a bioink that is biocompatible, with minimum to no cytotoxicity & inflammatory-response. Here, we compare tunicate-derived nanocellulose (NC) against widely used semi-synthetic, gelatin methacrylate (GelMA) biomaterial for best mirroring HNSCC TME via bioprinting technology.
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Azhakesan et al. (2024) studied this question.
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