The Cyclopie: About an Observation and Review of Literature

Cyclops are the most severe form of holoprosencephaly.It is a rare polygenetic malformation that occurs during early embryonic development.It is a single eye, or by extension, two eyes, contained in the same median orbit.We report a case of cyclopy at the Aristide Le Dantec National University Hospital.It was premature of 35 SA + 05 days, born of a pregnancy complicated by eclampsia, without pathological history in the parents.A prenatal ultrasound had objectified a severe hydro-amnios with a microcephaly.The ophthalmological examination showed a single median orbital cavity containing two different sized eyeballs.The general examination objectified a microcephaly, an arhinia and an abscess of the right foot.The orbito-cerebral CT showed a major cerebral malformation with microcrania type and a cyclopia.The child died after 27 days of ectopic life from respiratory distress.Cyclopia is a non-viable malformation whose prenatal diagnosis is based on the realization of an obstetric ultrasound from 12eSA.An etiological assessment is essential, it makes it possible to look for environmental and genetic risk factors.