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April 16, 2024Journal of Alzheimer s Disease

Association of Basal Forebrain Volume with Amyloid, Tau, and Cognition in Alzheimer’s Disease

Han Soo Yoo Han‐Kyeol Kim Jae‐Hoon Lee Joong‐Hyun Chun Hye Sun Lee Michel J. Grothe Stefan Teipel Enrica Cavedo Andrea Vergallo Harald Hampel Young Hoon Ryu Hanna Cho Chul Hyoung Lyoo

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Abstract

Degeneration of cholinergic basal forebrain (BF) neurons characterizes Alzheimer's disease (AD). However, what role the BF plays in the dynamics of AD pathophysiology has not been investigated precisely.

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Yoo et al. (2024) studied this question.

synapsesocial.com/papers/68e6ee1fb6db6435876692b5 https://doi.org/10.3233/jad-230975

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Association of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease2024 · 24 citations
2Invited Perspective on “Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer’s disease”Original Research · 2026
3Effects of strategic white matter hyperintensities of cholinergic pathways on basal forebrain volume in patients with amyloid-negative neurocognitive disorders2024 · 3 citations
4Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer's disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort studyClinical Trial · 2026 · 4 citations
5The cholinergic basal forebrain and its role in neurodegeneration2025 · 6 citations

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Decreased cholinergic nucleus 4 basal forebrain density is associated with disease progression in Alzheimer’s Disease.2024
Alzheimer's Co‐Pathology Burden on Basal Forebrain Atrophy and Cognitive Impairment in Dementia with Lewy Bodies: A Cross‐Sectional Pilot Study2026
Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease2026

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