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April 16, 2024Stem Cell Research & TherapyOpen Access

Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells

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Authors

HLHuan-Ting LinThe University of TokyoMTMasatoshi TakagiTokyo Medical and Dental UniversityKKKenji KubaraEisai (Japan)

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Cite This Study

Lin et al. (2024) studied this question.

synapsesocial.com/papers/68e6ef25b6db643587669d47https://doi.org/10.1186/s13287-024-03723-2
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Also Consider

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  1. 1Modeling KRAS mutations in KMT2A::MLLT3 acute myeloid leukemia promotes leukemic progression and transcriptional rewiring2026
  2. 2KRASG12V Enhances Proliferation and Initiates Myelomonocytic Differentiation in Human Stem/Progenitor Cells via Intrinsic and Extrinsic Pathways2010 · 28 citations
  3. 3KRAS G12D Blocks Erythroid Differentiation and Promotes Inflammatory Pathways at the Single Cell Level in Myeloid Malignancies 22515712026
  4. 4Human HSPCs CRISPR-engineered to endogenously express oncogenic NRAS generate a transplantable lethal myeloid malignancy targetable with novel RAS therapeutics2025
  5. 5Abstract 3540: <i>KRAS</i> allelic imbalance reshapes tumor evolution through selective clonal outgrowth and chromosomal instability in NSCLC2026