What question did this study set out to answer?

The central aim is to understand the genetic factors that influence the response or resistance to RAS inhibitors in multiple myeloma.

March 7, 2026Cancer Research

Abstract B027: Functional genomics studies identify determinants of response vs. resistance to pharmacological inhibitors of RAS in multiple myeloma

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Authors

ABArnold BolomskyNational Institutes of Health TSTorsten SteinbrunnDana-Farber Cancer Institute OAOmar S. Al‐OdatNational Cancer Institute

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Implication

Functional genomics analyzes genetic factors influencing responses to RAS inhibitors in multiple myeloma, suggesting personalized treatment approaches.

Key Points

The central aim is to understand the genetic factors that influence the response or resistance to RAS inhibitors in multiple myeloma.
Conducted functional genomics assessments using CRISPR knockout and activation screens across multiple myeloma cell lines.
Utilized various KRAS-selective inhibitors and pan-RAS inhibitors in preclinical models.
Tracked genomic changes using DNA barcoding to examine clonal response to treatment.
Identified heterogeneous responses to RAS inhibitors among different multiple myeloma cell lines.
Note of significant differences in gene expression profiles compared to CRISPR knockout hits.
Resistance mechanisms were linked to alterations in upstream surface receptors and RAS-MAPK signaling regulators.

Cite This Study

Bolomsky et al. (2026) studied this question.

synapsesocial.com/papers/69abc2725af8044f7a4ec0cf https://doi.org/10.1158/1538-7445.rasoncother26-b027

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Implication

Functional genomics analyzes genetic factors influencing responses to RAS inhibitors in multiple myeloma, suggesting personalized treatment approaches.

Abstract B027: Functional genomics studies identify determinants of response vs. resistance to pharmacological inhibitors of RAS in multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract B027: Functional genomics studies identify determinants of response vs. resistance to pharmacological inhibitors of RAS in multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

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