What type of study is this?

This is a In Vitro Study study.

What question did this study set out to answer?

To identify molecular determinants affecting response and resistance to KRAS inhibitors in multiple myeloma.

December 8, 2025BloodOpen Access

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Functional genomics reveals IL-6 and oxidative stress impact response to KRAS inhibitors in multiple myeloma.

To identify molecular determinants affecting response and resistance to KRAS inhibitors in multiple myeloma.
Evaluated pharmacological inhibitors in preclinical multiple myeloma models.
Conducted genome-scale CRISPR knockout and activation screens across diverse MM lines.
Assessed the impact of tumor microenvironment and cytokines on inhibitor sensitivity.
IL-6 in the microenvironment attenuated KRAS inhibitor response in multiple myeloma cells.
Identified distinct genomic landscapes influencing Ras inhibitor response in MM.
Resistance-associated hits included genes regulating Ras/MAPK and oxidative stress.

Steinbrunn et al. (2025) studied this question.

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