Mp75-02 Causal Relationship Between Lower Urinary Tract Symptoms and Frailty: The Chicken or the Egg Dilemma

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction (Excluding OAB) (MP75)1 May 2024MP75-02 CAUSAL RELATIONSHIP BETWEEN LOWER URINARY TRACT SYMPTOMS AND FRAILTY: THE CHICKEN OR THE EGG DILEMMA Shogo Hosogoe, Naoki Fujita, Teppei Okamoto, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama, and Shingo Hatakeyama Shogo HosogoeShogo Hosogoe , Naoki FujitaNaoki Fujita , Teppei OkamotoTeppei Okamoto , Hayato YamamotoHayato Yamamoto , Takahiro YoneyamaTakahiro Yoneyama , Yasuhiro HashimotoYasuhiro Hashimoto , Chikara OhyamaChikara Ohyama , and Shingo HatakeyamaShingo Hatakeyama View All Author Informationhttps://doi.org/10.1097/01.JU.0001008676.21744.5f.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Lower urinary tract symptoms (LUTS) and frailty are common among older adults and remarkably affect their daily lives. Both LUTS and frailty are related to multiple comorbidities and unfavorable outcomes. Furthermore, several studies have revealed close associations between LUTS and frailty. Since a longitudinal study has shown the association of LUTS severity with decreased mobility and worsening activities of daily living among older men, we hypothesized that the effect of LUTS on frailty might be stronger than that of frailty on LUTS. Accordingly, this longitudinal study investigated the natural history and causal relationship between LUTS and frailty in community-dwelling adults over a 5-year period. METHODS: We longitudinally evaluated the temporal changes and the bidirectional relationships between frailty and LUTS in 247 community dwelling adults at baseline and at a 5-year follow-up. We used the Fried phenotype (phenotype-based frailty), 5-item modified frailty index (5i-mFI; comorbidity-based frailty), and frailty discriminant score (comprehensive frailty assessment) to evaluate frailty. LUTS were evaluated using the international prostate symptom score (IPSS) and overactive bladder symptom score (OABSS). RESULTS: We analyzed 247 participants with a median age of 60 years. The median IPSS and OABSS were significantly increased over the 5 years from 2 to 3 and from 1 to 2, respectively (Figure 1). The proportion of frail individuals did not increase significantly over the 5 years. Of the three frailty assessment tools, the 5i-mFI score significantly increased between 2014 and 2019 (Figure 2). A cross-lagged panel analysis using the 5i-mFI score revealed that the path coefficients were significantly associated with LUTS (2014) to frailty (2019) but not with frailty (2014) to LUTS (2019) (Figure 3). CONCLUSIONS: The causal effect of LUTS on frailty was significant in community-dwelling adults. Download PPTDownload PPTDownload PPT Source of Funding: The authors did not receive support from any organization for the submitted work © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1231 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Shogo Hosogoe More articles by this author Naoki Fujita More articles by this author Teppei Okamoto More articles by this author Hayato Yamamoto More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Chikara Ohyama More articles by this author Shingo Hatakeyama More articles by this author Expand All Advertisement PDF downloadLoading ...