PD43-08 SERUM SEROTONIN LEVELS AS a POTENTIAL RISK FACTOR FOR OVERACTIVE BLADDER IN A COMMUNITY-DWELLING POPULATION: A 4-YEAR LONGITUDINAL STUDY

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Overactive Bladder I (PD43)1 May 2024PD43-08 SERUM SEROTONIN LEVELS AS a POTENTIAL RISK FACTOR FOR OVERACTIVE BLADDER IN A COMMUNITY-DWELLING POPULATION: A 4-YEAR LONGITUDINAL STUDY Teppei Okamoto, Osamu Soma, Naoki Fujita, Hayato Yamamoto, Shingo Hatakeyama, and Chikara Ohyama Teppei OkamotoTeppei Okamoto , Osamu SomaOsamu Soma , Naoki FujitaNaoki Fujita , Hayato YamamotoHayato Yamamoto , Shingo HatakeyamaShingo Hatakeyama , and Chikara OhyamaChikara Ohyama View All Author Informationhttps://doi.org/10.1097/01.JU.0001009568.19060.25.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Serotonin [5-hydroxytryptamine (5-HT)], which is synthesized from L-tryptophan primarily in the gut and brainstem, is one of the major neurotransmitters associated with micturition. Several cross-sectional studies have shown that lower serum 5-HT levels are independently associated with the presence of overactive bladder (OAB). However, the causal relationship between the two has not been established. We therefore investigated the longitudinal association between serum 5-HT levels and OAB in a community-dwelling population. METHODS: A 4-year longitudinal study was conducted involving 615 subjects who participated in the Iwaki Health Promotion Project in Hirosaki, Japan, in both 2015 and 2019. OAB was defined as experiencing urinary urgency at least once a week with an Overactive Bladder Symptom Score (OABSS) of ≥3. Baseline data from 2015, including serum 5-HT levels, other laboratory data, and comorbidity information, were used for analysis. The association between serum 5-HT levels and incident OAB in 2019 (OAB-2019) was examined using multivariate logistic regression analyses. RESULTS: The study included 250 men and 365 women, of whom 74 individuals (29 men and 45 women) met the diagnostic criteria for OAB in 2019. Significant differences were observed between the OAB-2019 and non-OAB-2019 groups, including age, chronic kidney disease, irritable bowel syndrome, hypertension, glycemic status, mental status, and OAB in 2015. Participants in the OAB-2019 group had significantly lower serum 5-HT levels compared to the non-OAB-2019 group (100 vs. 129 ng/mL, p<0.001). After adjusting for confounders, multivariable analysis revealed that serum 5-HT levels <134 ng/mL (odds ratio: 2.48, 95% confidence interval: 1.39-5.83, p=0.004), age, mental status, and OAB in 2015 independently served as risk factors for OAB-2019. CONCLUSIONS: Low serum 5-HT levels may be associated with an increased risk of OAB. Further research is needed to elucidate the underlying mechanisms responsible for this association. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e901 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Teppei Okamoto More articles by this author Osamu Soma More articles by this author Naoki Fujita More articles by this author Hayato Yamamoto More articles by this author Shingo Hatakeyama More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement PDF downloadLoading ...