Mp77-01 Longitudinal Assessment of Perioperative, Postoperative and Early Health Related Quality of Life Outcomes: Head to Head Comparison Between Ileal Conduit and Padua Ileal Neobladder From a Single Center Randomised Controlled Trial

You have accessJournal of UrologyBladder Cancer: Invasive VI (MP77)1 May 2024MP77-01 LONGITUDINAL ASSESSMENT OF PERIOPERATIVE, POSTOPERATIVE AND EARLY HEALTH RELATED QUALITY OF LIFE OUTCOMES: HEAD TO HEAD COMPARISON BETWEEN ILEAL CONDUIT AND PADUA ILEAL NEOBLADDER FROM A SINGLE CENTER RANDOMISED CONTROLLED TRIAL Riccardo Mastroianni, Gabriele Tuderti, Umberto Anceschi, Alfredo Maria Bove, Aldo Brassetti, Simone D'Annunzio, Mariaconsiglia C. Ferriero, Leonardo Misuraca, Salvatore Guaglianone, Michele Gallucci, and Giuseppe Simone Riccardo MastroianniRiccardo Mastroianni , Gabriele TudertiGabriele Tuderti , Umberto AnceschiUmberto Anceschi , Alfredo Maria BoveAlfredo Maria Bove , Aldo BrassettiAldo Brassetti , Simone D'AnnunzioSimone D'Annunzio , Mariaconsiglia C. FerrieroMariaconsiglia C. Ferriero , Leonardo MisuracaLeonardo Misuraca , Salvatore GuaglianoneSalvatore Guaglianone , Michele GallucciMichele Gallucci , and Giuseppe SimoneGiuseppe Simone View All Author Informationhttps://doi.org/10.1097/01.JU.0001009404.49693.12.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The impact of urinary diversion (UD) on HRQoL is too often underinvestigated, assuming orthotopic neobladder to be the optimal choice for patients. In this study prospective RCT (NCT03434132), we assessed early HRQoL modifications between patients receiving Ileal Conduit (IC) or orthotopic Padua Ileal Bladder (PIB). METHODS: Patients were eligible if they had a diagnostic TURBt with cT2-4cN0cM0, or recurrent HG NMIBC and no anesthesiologic contraindications to robotic surgery. Between Jan 2018 and Sept 2020, patients were enrolled with a covariate adaptive randomization process based on: BMI, ASA, baseline Hgb, UD, neoadjuvant chemo and cTstage. Data from EORTC QLQ-C30 and QLQ-BLM30 questionnaires were collected. Normally distributed HRQoL continuous variables were compared with paired t test. A generalized linear mixed effect regression (GLMER) model including a random effect at patients level was implemented to test variation of HRQoL items along time and between groups. RESULTS: Out of 116 patients enrolled, 106 reached at least 6 mo of fup. Baseline outcomes were reported Table 1. Patients who underwent IC were older and with a higher ASA score (p<0.034). Peri- and post-operative outcomes were comparable between groups, except for operative time (p=0.032). At 6 mo HRQoL evaluation, both cohorts reported significant worsening in terms of physical, and sexual functioning, with a significant impairment of fatigue, dyspnea, constipation and body image (all p<0.025). Patients receiving PIB were also more likely to report impairment of role, social functioning, appetite loss, diarrhea and financial difficulties (all p<0.02). At GLMER analysis PIB cohort displayed a significant impairment in terms of social functioning and financial difficulties, while IC cohort experienced a significant impact of sexual functioning (p<0.041, Table 3). CONCLUSIONS: Despite comparable global health status, patients receiving PIB are more likely to experience favourable sexual function recovery but significant social function impairment and financial difficulties. Preoperative counselling for patients selected for PIB should discuss longer postoperative recovery and social functioning. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1251 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Riccardo Mastroianni More articles by this author Gabriele Tuderti More articles by this author Umberto Anceschi More articles by this author Alfredo Maria Bove More articles by this author Aldo Brassetti More articles by this author Simone D'Annunzio More articles by this author Mariaconsiglia C. Ferriero More articles by this author Leonardo Misuraca More articles by this author Salvatore Guaglianone More articles by this author Michele Gallucci More articles by this author Giuseppe Simone More articles by this author Expand All Advertisement PDF downloadLoading ...