Mp08-01 Prospective Evaluation of Quality of Life, Psychosocial Distress, Functional Outcomes, and Return to Work in 842 German Bladder Cancer Patients Two Years After Radical Cystectomy and Urinary Diversion

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP08)1 May 2024MP08-01 PROSPECTIVE EVALUATION OF QUALITY OF LIFE, PSYCHOSOCIAL DISTRESS, FUNCTIONAL OUTCOMES, AND RETURN TO WORK IN 842 GERMAN BLADDER CANCER PATIENTS TWO YEARS AFTER RADICAL CYSTECTOMY AND URINARY DIVERSION Henning Bahlburg, Moritz J. Reike, Karl H. Tully, Peter Bach, Marius C. Butea-Bocu, Florian Roghmann, Joachim Noldus, and Guido Müller Henning BahlburgHenning Bahlburg , Moritz J. ReikeMoritz J. Reike , Karl H. TullyKarl H. Tully , Peter BachPeter Bach , Marius C. Butea-BocuMarius C. Butea-Bocu , Florian RoghmannFlorian Roghmann , Joachim NoldusJoachim Noldus , and Guido MüllerGuido Müller View All Author Informationhttps://doi.org/10.1097/01.JU.0001008780.87855.57.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: This study aimed to investigate quality of life (QoL), psychosocial distress (PD), functional outcomes, and return to work (RTW) after radical cystectomy (RC) and urinary diversion for ileal neobladder (INB) or ileal conduit (IC) in a contemporary German cohort. METHODS: Patients undergoing inpatient rehabilitation after RC and urinary diversion between April 2018 and December 2019 in one high-volume rehabilitation center were surveyed regarding QoL (EORTC-QLQ-C30 & -BLM30), PD (QSC-R10), and functional outcomes (ICIQ-SF, IIEF-5, EHS) at the beginning (T1) and the end of IR (T2), 6 months (T3), 12 months (T4), and 24 months (T5) after RC. RESULTS: Eight-hundred forty-two patients (683 male, 159 female; 395 INB, 447 IC) were included. Patients with an IC suffered more often from locally advanced disease (≥pT3; 41.4% vs 24.1%, p<0.001) and lymph node metastases (19.2% vs 11.4%, p=0.002). Health-related QoL improved steadily during follow-up. At T5, patients with an INB reported superior physical functioning, role functioning, less fatigue, less constipation, more diarrhea, and more financial difficulties (p<0.001, respectively). High PD (QSC-R10 ≥15) was reported by 42.6% of patients at T5. Multivariable regression analyses identified IC (OR 1.532; 95% CI 1.048–2.239; p=0.028), male sex (OR 1.669; 95% CI 1.021–2.728, p=0.041), and patient age ≤59 years (OR 1.898; 95% CI 1.169–3.081, p=0.01) as independent predictors for high PD at T5. Almost 42% of female patients reported severe urinary incontinence (ICIQ-SF ≥11) at T5. The majority of men reported erectile dysfunction, even after nerve-sparing surgery. A successful RTW was reported by 68.2% of previously employed patients (n=230). Multivariable regression analyses identified RTW as a predictor for lower PD (p<0.001) and higher QoL (p=0.018), while age (OR 7.730; 95% CI 3.369-17.736; p<0.001) was the only predictor of a successful RTW at T5. CONCLUSIONS: Female patients should be informed about worse continence rates. Conversely, men should be educated about erectile dysfunction. Aftercare should include psycho-oncologic counseling, especially for patients at risk. Further efforts by authorities and employers are needed to enable a RTW for more cancer survivors. Source of Funding: This study was funded by the "Nordrhein-Westfalen Association for the Fight Against Cancer, Germany". The funder had no influence on the study design, data collection and analysis, decision to present at this conference, or preparation of the abstract © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e114 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Henning Bahlburg More articles by this author Moritz J. Reike More articles by this author Karl H. Tully More articles by this author Peter Bach More articles by this author Marius C. Butea-Bocu More articles by this author Florian Roghmann More articles by this author Joachim Noldus More articles by this author Guido Müller More articles by this author Expand All Advertisement PDF downloadLoading ...