Pd17-11 Cribriform Pattern Associated Lymphatic Metastases Detected by Prostate-Specific Membrane Antigen in Post-Radical Prostatectomy Biochemically Recurrent Patients

You have accessJournal of UrologyProstate Cancer: Staging I (PD17)1 May 2024PD17-11 CRIBRIFORM PATTERN ASSOCIATED LYMPHATIC METASTASES DETECTED BY PROSTATE-SPECIFIC MEMBRANE ANTIGEN IN POST-RADICAL PROSTATECTOMY BIOCHEMICALLY RECURRENT PATIENTS Rui Miguel Marques Bernardino, Rashid Sayyid, Zizo Al-Daqqaq, Jessica Cockburn, Mohamad Berjaoui, Ur Metser, Alejandro Berlin, Theodorus van der Kwast, and Neil Fleshner Rui Miguel Marques BernardinoRui Miguel Marques Bernardino , Rashid SayyidRashid Sayyid , Zizo Al-DaqqaqZizo Al-Daqqaq , Jessica CockburnJessica Cockburn , Mohamad BerjaouiMohamad Berjaoui , Ur MetserUr Metser , Alejandro BerlinAlejandro Berlin , Theodorus van der KwastTheodorus van der Kwast , and Neil FleshnerNeil Fleshner View All Author Informationhttps://doi.org/10.1097/01.JU.0001010044.70939.31.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Cribriform morphology is indicative of poorer oncologic outcomes and is associated with distinct intrinsic cellular pathway changes and tumor microenvironments that can influence the patterns of metastatic dissemination. The aim of this study is to investigate whether the detection of cribriform morphology in prostatectomy specimens from patients experiencing biochemical recurrence following radical prostatectomy (RP) is linked to the presence of metastasis identified through prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT), and whether it is associated with a unique spread pattern. METHODS: A cross-sectional analysis was conducted of all prostate cancer patients with biochemical recurrence after RP undergoing 18F-DCFPyL-PET/CT between December 2018 and February 2021. Outcomes were presence of any metastasis in the overall cohort and lymphatic versus bone/visceral metastases among patients with metastatic disease. The associations between the presence of intraductal (IDC) and/or invasive cribriform (ICC) carcinoma on the RP specimen and study outcomes were evaluated using logistic regression analyses. RESULTS: The cohort included 176 patients. IDC and ICC were observed in 77 (43.8%) and 80 (45.5%) RP specimens, respectively. The median time from RP to PSMA-PET/CT was 5.0 yr. The median serum prostate-specific antigen level at PSMA- PET/CT was 1.12 ng/ml. Overall, metastasis was observed in 77 patients, of whom 58 were had lymphatic-only metastasis. On a multivariable analysis, presence of IDC on RP was associated with increased odds of overall metastasis (odds ratio [OR]: 2.17; 95% confidence interval [CI]: 1.07–4.45; p=0.033). Presence of ICC on RP was associated with significantly increased odds of lymphatic versus bone/visceral metastases (OR: 3.13; 95% CI: 1.09–21.7; p=0.004). CONCLUSIONS: The existence of cribriform morphology in radical prostatectomy (RP) specimens from patients experiencing biochemical failure post-RP is linked to higher probabilities of PSMA-PET/CT-detected metastases, particularly with a prevailing lymphatic spread pattern. These results bear significance for the formulation and assessment of post-RP salvage treatments. Source of Funding: RB has a FCT PhD Doctoral Grant (2022.13386.BD) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e374 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Rui Miguel Marques Bernardino More articles by this author Rashid Sayyid More articles by this author Zizo Al-Daqqaq More articles by this author Jessica Cockburn More articles by this author Mohamad Berjaoui More articles by this author Ur Metser More articles by this author Alejandro Berlin More articles by this author Theodorus van der Kwast More articles by this author Neil Fleshner More articles by this author Expand All Advertisement PDF downloadLoading ...