Mp74-05 Is Prostate Biopsy a Reliable Method for Detecting Cribriform and Intraductal Carcinoma?

You have accessJournal of UrologyProstate Cancer: Detection & Screening VI (MP74), Moderated Poster 741 May 2024MP74-05 IS PROSTATE BIOPSY A RELIABLE METHOD FOR DETECTING CRIBRIFORM AND INTRADUCTAL CARCINOMA? Rui Miguel Marques Bernardino, Rashid Sayyid, Katherine Lajkosz, Zizo Al-Daqqaq, Jessica Cockburn, Shideh Abedi, Julian Chavarriaga, Ricardo Leao, Alejandro Berlin, Theodorus van der Kwast, and Neil Fleshner Rui Miguel Marques BernardinoRui Miguel Marques Bernardino , Rashid SayyidRashid Sayyid , Katherine LajkoszKatherine Lajkosz , Zizo Al-DaqqaqZizo Al-Daqqaq , Jessica CockburnJessica Cockburn , Shideh AbediShideh Abedi , Julian ChavarriagaJulian Chavarriaga , Ricardo LeaoRicardo Leao , Alejandro BerlinAlejandro Berlin , Theodorus van der KwastTheodorus van der Kwast , and Neil FleshnerNeil Fleshner View All Author Informationhttps://doi.org/10.1097/01.JU.0001008632.59099.b9.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The presence of cribriform morphology and intraductal carcinoma (IDC) in prostate biopsies and radical prostatectomy specimens is an adverse prognostic feature that can be used to guide treatment decisions. The objective of our study is to assess how accurately biopsies can detect cribriform morphology and IDC cancer by examining matched biopsy and prostatectomy samples. METHODS: Patients who underwent radical prostatectomy between January 2015 and December 2022 and had cribriform morphology and/or IDC in the surgical specimen were included in the study. We used detection sensitivity to evaluate the level of agreement between biopsy and prostatectomy samples regarding the presence of cribriform morphology and IDC. RESULTS: Of the 287 men who underwent radical prostatectomy, 241 (84%) had cribriform morphology and 161 (56%) had IDC on final pathology. The sensitivity of prostate biopsy, using radical prostatectomy as the reference, was 42.4% (95% confidence interval [CI] 36–49%) for detection of cribriform morphology and 44.1% (95% CI 36–52%) for detection of IDC. The sensitivity of prostate biopsy for detection of either IDC or cribriform morphology was 52.5% (95% CI 47–58%). Among patients who underwent multiparametric magnetic resonance imaging–guided biopsies, the sensitivity was 54% (95% CI 39–68%) for detection of cribriform morphology and 37% (95% CI 19–58%) for detection of IDC. CONCLUSIONS: Biopsy has low sensitivity for detecting cribriform morphology and IDC. These limitations should be incorporated into clinical decision-making. Biomarkers for better detection of these histological patterns are needed. Download PPT Source of Funding: RB has a FCT PhD grant (2022.13386.BD) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1194 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Rui Miguel Marques Bernardino More articles by this author Rashid Sayyid More articles by this author Katherine Lajkosz More articles by this author Zizo Al-Daqqaq More articles by this author Jessica Cockburn More articles by this author Shideh Abedi More articles by this author Julian Chavarriaga More articles by this author Ricardo Leao More articles by this author Alejandro Berlin More articles by this author Theodorus van der Kwast More articles by this author Neil Fleshner More articles by this author Expand All Advertisement PDF downloadLoading ...