Pd04-11 Survivorship After Kidney Cancer in Children, Adolescents and Young Adults – What Is Causing Death and When?

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You have accessJournal of UrologyPediatrics I (PD04)1 May 2024PD04-11 SURVIVORSHIP AFTER KIDNEY CANCER IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS – WHAT IS CAUSING DEATH AND WHEN? Naveen Gupta, Jonathan Walker, Kathleen Kieran, Will Cranford, Christopher McLouth, Nicholas G. Cost, and Amanda F. Saltzman Naveen GuptaNaveen Gupta , Jonathan WalkerJonathan Walker , Kathleen KieranKathleen Kieran , Will CranfordWill Cranford , Christopher McLouthChristopher McLouth , Nicholas G. CostNicholas G. Cost , and Amanda F. SaltzmanAmanda F. Saltzman View All Author Informationhttps://doi.org/10.1097/01.JU.0001008812.05762.7f.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To determine the cause-specific mortality among patients<40 years-old after successful treatment for kidney cancers. METHODS: Information for patients 0-40 y at diagnosis of kidney cancer, who eventually died (n=1,323) were retrieved from the Surveillance, Epidemiology, and End Results (SEER) 2000-2020 incidence database. Standardized mortality ratios (SMR) and 95% confidence intervals for causes of death were calculated for 1323 individuals against healthy controls matched for sex, race, age and year of death for the US population and stratified by time from diagnosis. RESULTS: Overall, the highest adjusted risk of death at any time was the primary cancer (SMR 1,457.7, 95%CI: 1,379.9-1,579.4), followed by other malignancies (SMR 4.85, 95%CI: 4.02-5.80). Patients with kidney cancers were at a higher overall risk of non-oncologic death compared to matched controls for 10 years post-diagnosis. Figure 1 summarizes the largest significant results for non-oncologic causes of death. Compared to matched controls, and aside from death due to the primary cancer, the highest overall causes of death were benign/unknown neoplasms, nephrotic/nephritic pathologies, and complications of pregnancy/childbirth (all SMR>10). The causes of death at various times after diagnosis varied considerably. CONCLUSIONS: For childhood kidney cancer survivors, there are shifting mortality patterns over time. The highest overall risk of death is due to kidney cancer or secondary malignancies. Overall survivorship should focus strategies to identify and address other neoplasms, renal pathology, and childbearing. Our findings raise the question of prioritizing nephron-sparing management strategies to limit chronic kidney disease related mortality in this population. Download PPT Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e87 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Naveen Gupta More articles by this author Jonathan Walker More articles by this author Kathleen Kieran More articles by this author Will Cranford More articles by this author Christopher McLouth More articles by this author Nicholas G. Cost More articles by this author Amanda F. Saltzman More articles by this author Expand All Advertisement PDF downloadLoading ...