Mp61-05 What Are the Causes of Death Among Men Treated for Penile Cancer?

You have accessJournal of UrologyPenile & Testicular Cancer II (MP61)1 May 2024MP61-05 WHAT ARE THE CAUSES OF DEATH AMONG MEN TREATED FOR PENILE CANCER? Darren Sanchez, Panayiotis Kontoyiannis, Arjun Peddireddy, Jerril Jacob, Alberto Martini, Akshay Sood, and Curtis Pettaway Darren SanchezDarren Sanchez , Panayiotis KontoyiannisPanayiotis Kontoyiannis , Arjun PeddireddyArjun Peddireddy , Jerril JacobJerril Jacob , Alberto MartiniAlberto Martini , Akshay SoodAkshay Sood , and Curtis PettawayCurtis Pettaway View All Author Informationhttps://doi.org/10.1097/01.JU.0001009536.58867.87.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The natural history of treated penile cancer remains poorly understood owing to its rarity. We sought to evaluate the ultimate cause of death in patients with penile cancer to identify strategies to improve survival. METHODS: We conducted a retrospective review of all penile cancer patients who received care at the University of Texas, M.D. Anderson Cancer Center (MDACC, 1980-2020, n=534). The primary tumor was treated using standard care practices following clinical staging with total penectomy, partial penectomy, or biopsy alone +/− pelvic or inguinal nodal dissection depending on regional lymph node metastasis and with/without chemotherapy as appropriate for disease burden. Stage-specific cumulative incidence curves were plotted evaluating mortality from penile cancer vs other causes: dead of disease (DOD), dead with disease (DWD), dead without disease (DWOD), and alive. RESULTS: Among the 450 patients with complete baseline information, the median age at diagnosis was 61 years (51–70). 121 (26.9%) patients presented pTis/Ta/T0 disease, while 146 (32.4%), 135 (30.0%), and 48 (10.6%) had pT1, pT2, and >=pT3 (N0–N3, M0-1) disease, respectively. At a median follow-up of 52 months, 119 patients had died in total. Among the patients who died, 55 (46%) died of penile cancer and 64 (54%) died of other causes. Of the 55 men who died from penile cancer, 84% died from distant metastatic progression, while 4%, 5%, and 7% died from regional nodal progression including bleeding, DVT/PE related to lymphadenopathy, and sepsis, respectively. The overall 5-year estimated penile cancer specific mortality rate was 12.4%, with no men dying of disease after treatment in the pTis/Ta/T0 group. While, the 5-year disease specific mortality rate in patients with pTanyN+ disease was 25.9%. Finally, the 5-year estimated other-cause mortality rate was 6.1% (Figure 1). CONCLUSIONS: This study demonstrated that death from penile cancer is rare among treated patients with non-invasive penile cancer. Patients with lymph node positive disease exhibit the highest likelihood of dying of the disease. Among patients dying of penile cancer, distant metastatic progression was the most common cause of death in comparison to regional nodal complications. Download PPT Source of Funding: The University of Texas M.D. Anderson Cancer Center Department of Urology © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1011 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Darren Sanchez More articles by this author Panayiotis Kontoyiannis More articles by this author Arjun Peddireddy More articles by this author Jerril Jacob More articles by this author Alberto Martini More articles by this author Akshay Sood More articles by this author Curtis Pettaway More articles by this author Expand All Advertisement PDF downloadLoading ...