Mp01-17 Natural History of Subcentimeter Pulmonary Nodules in Clinical Stage I Seminoma Patients

You have accessJournal of UrologyPenile & Testicular Cancer I (MP01)1 May 2024MP01-17 NATURAL HISTORY OF SUBCENTIMETER PULMONARY NODULES IN CLINICAL STAGE I SEMINOMA PATIENTS Nuphat Yodkhunnatham, Dhruv Puri, Kshitij Pandit, Austin Leonard, Isabella Dolendo, Joanna Langner, Jacob Roberts, Julian Cortes, Amirali Salmasi, Rana Mckay, Brent Rose, Frederick Millard, and Aditya Bagrodia Nuphat YodkhunnathamNuphat Yodkhunnatham , Dhruv PuriDhruv Puri , Kshitij PanditKshitij Pandit , Austin LeonardAustin Leonard , Isabella DolendoIsabella Dolendo , Joanna LangnerJoanna Langner , Jacob RobertsJacob Roberts , Julian CortesJulian Cortes , Amirali SalmasiAmirali Salmasi , Rana MckayRana Mckay , Brent RoseBrent Rose , Frederick MillardFrederick Millard , and Aditya BagrodiaAditya Bagrodia View All Author Informationhttps://doi.org/10.1097/01.JU.0001008660.87408.90.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Subcentimeter pulmonary nodules found in Stage I (CS I) seminoma may be early pulmonary metastases or incidental, benign entities that may lead to patient anxiety and overtreatment. This study aims to demonstrate the incidence and natural history of subcentimeter pulmonary nodules in CS I seminoma patients. METHODS: A retrospective study reviewing the medical records of CS I seminoma patients treated at UC San Diego Health between 2003 and 2023. Data collection included demographics, serum tumor markers (STM), imaging reports, pathologic findings, treatment records, and records of disease relapse. We described subcentimeter pulmonary nodule as a finding either from a chest X-ray (CXR) or a CT scan of the chest at the time of seminoma diagnosis, with a size <1 cm. The incidence of subcentimeter pulmonary nodules and relationship with disease relapse was explored. RESULTS: 79 patients with CS I seminoma were included in the study, and mean follow-up time was 40 months. Our general practice is to observe all patients with stage I seminoma unless extenuating circumstances. Among them, 21 patients were found to have subcentimeter pulmonary nodules, all which were diagnosed on CT scan of chest, resulting in an incidence rate of 26.6%. Notably, there was no statistically significant difference in the occurrence of subcentimeter pulmonary nodules between patients with CS IA and CS IB (27.9% and 22.2%, respectively, p=0.227). Four patients (5%) experienced disease relapse. None of the patients that had a relapse had an incidental subcentimeter nodules. Six patients received adjuvant chemotherapy (CMT); 1 patient had a pulmonary nodule and did not relapse; 1 patient experienced disease relapse without nodule. 10 patients underwent adjuvant radiation (RT), with no recurrence observed despite 4 of them having nodules. Additionally, 5 patients with nodules received adjuvant CMT or RT; none recurred. 16 patients with nodules were under surveillance, none recurred. CONCLUSIONS: The incidence of subcentimeter pulmonary nodule in CS I seminoma patient is high. Subcentimeter nodules do not appear to be related to risk of disease relapse. Our findings suggests that patients with CS I seminoma and incidental subcentimeter pulmonary nodule can be counseled that this is a common, clinically insignificant finding. Further validation in a larger population is necessary. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e9 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Nuphat Yodkhunnatham More articles by this author Dhruv Puri More articles by this author Kshitij Pandit More articles by this author Austin Leonard More articles by this author Isabella Dolendo More articles by this author Joanna Langner More articles by this author Jacob Roberts More articles by this author Julian Cortes More articles by this author Amirali Salmasi More articles by this author Rana Mckay More articles by this author Brent Rose More articles by this author Frederick Millard More articles by this author Aditya Bagrodia More articles by this author Expand All Advertisement PDF downloadLoading ...