Mp06-03 Efficacy of Endoscopic Urethral Stricture Treatment Using Lighted Catheter: An Animal Pilot Trial

You have accessJournal of UrologyReconstruction: Urethral Reconstruction (including stricture) I (MP06)1 May 2024MP06-03 EFFICACY OF ENDOSCOPIC URETHRAL STRICTURE TREATMENT USING LIGHTED CATHETER: AN ANIMAL PILOT TRIAL Guanqun Li, Elizabeth Bearrick, Joshua Sterling, Connor Policastro, Tiffany Caza, Daniel Zaccarini, Gennady Bratslavsky, and Dmitriy Nikolavsky Guanqun LiGuanqun Li , Elizabeth BearrickElizabeth Bearrick , Joshua SterlingJoshua Sterling , Connor PolicastroConnor Policastro , Tiffany CazaTiffany Caza , Daniel ZaccariniDaniel Zaccarini , Gennady BratslavskyGennady Bratslavsky , and Dmitriy NikolavskyDmitriy Nikolavsky View All Author Informationhttps://doi.org/10.1097/01.JU.0001009452.79331.fd.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Red light (RL)and near-infrared light (NIR) were shown to provide positive photobiomodulation in multiple injury models. Such biostimulatory effects were utilized to promote wound healing by dampening inflammation, which plays a vital role in the early phase of tissue repair. We aimed at investigating light therapy in urethral stricture repair. Our hypothesis was that those rabbits treated with direct vision internal urethrotomy (DVIU) followed by light therapy have higher rates of stricture resolution on imaging and decreased inflammation on histologic specimen. METHODS: After IACUC and IRB approvals, a previously developed rabbit stricture model was used. After successful stricture induction, 24 adult male NZ rabbits were randomized into 3 groups: control, RL group, NIR group. All underwent DVIU followed by catheter insertion. Control group received 12-French silicone catheters without modifications. RL group received an engineered 12-French silicone catheter with red light (650nm) transmitted via fiberoptics through the catheter. NIR light group received an engineered catheter with NIR light (850nm). Treated animals received 5.4 J/cm2 of energy daily for 7 days. Catheters were then removed. The animals were sacrificed at 24 weeks following treatment, immediately after retrograde urethrograms (RUG) and urethroscopy performed by a surgeon blinded to the treatment arm. Radiographic images and histological specimens were reviewed by a radiologist and a pathologist, respectively (each blinded to the treatment arm). Detectable radiographic improvement was defined as at least 10% change in the lumen diameter. Histological specimens were assessed for fibrosis and inflammation. RESULTS: Stricture was successfully induced on 24 rabbits, which were then randomized, 8 per group. After stenosis induction the groups achieved a mean of 41%, 47% and 37% stenosis in the control, RL, and NIR groups respectively. After treatment, 5/8 (62.5%), 7/8 (87.5%) and 8/8 (100%) had detectable improvement in control, RL and NIR groups respectively. Additionally, the control group, 2 (25%) had worsening strictures, and 1 had a complete obliteration. No worsening stricture was found in either RL or NIR treatment arm. Chronic inflammation was significantly more pronounced in the control group, when compared to the NIR group (p=0.04). CONCLUSIONS: This pilot study successfully demonstrated feasibility of utilizing RL or NIR light therapy via engineered catheters. Such method, once optimized may allow for an application of this concept to use light therapy in augmenting management of urethral stricture disease. Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e52 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Guanqun Li More articles by this author Elizabeth Bearrick More articles by this author Joshua Sterling More articles by this author Connor Policastro More articles by this author Tiffany Caza More articles by this author Daniel Zaccarini More articles by this author Gennady Bratslavsky More articles by this author Dmitriy Nikolavsky More articles by this author Expand All Advertisement PDF downloadLoading ...