Mp13-16 Revealing the Disability and Illness Burden in Infertile Men: Key Findings From a Long-Term Longitudinal Study Utilizing the Years Lived With Disability Metric

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I (MP13)1 May 2024MP13-16 REVEALING THE DISABILITY AND ILLNESS BURDEN IN INFERTILE MEN: KEY FINDINGS FROM A LONG-TERM LONGITUDINAL STUDY UTILIZING THE YEARS LIVED WITH DISABILITY METRIC Fausto Negri, Edoardo Pozzi, Alessandro Bertini, Massimiliano Raffo, Federico Belladelli, Christian Corsini, Francesco Cattafi, Marco Oddo, Marco Malvestiti, Luca Boeri, Giuseppe Fallara, Eugenio Ventimiglia, Paolo Capogrosso, Federico Dehò, Alessia d'Arma, Francesco Montorsi, and Andrea Salonia Fausto NegriFausto Negri , Edoardo PozziEdoardo Pozzi , Alessandro BertiniAlessandro Bertini , Massimiliano RaffoMassimiliano Raffo , Federico BelladelliFederico Belladelli , Christian CorsiniChristian Corsini , Francesco CattafiFrancesco Cattafi , Marco OddoMarco Oddo , Marco MalvestitiMarco Malvestiti , Luca BoeriLuca Boeri , Giuseppe FallaraGiuseppe Fallara , Eugenio VentimigliaEugenio Ventimiglia , Paolo CapogrossoPaolo Capogrosso , Federico DehòFederico Dehò , Alessia d'Arma Alessia d'Arma , Francesco MontorsiFrancesco Montorsi , and Andrea SaloniaAndrea Salonia View All Author Informationhttps://doi.org/10.1097/01.JU.0001008832.14212.d6.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The Years Lived with Disability (YLD), is a WHO-validated parameter used for understanding disease burdens. Male factor infertility (MFI) is associated with higher risk of developing health-significant comorbidities. There are currently no studies that investigate the burden of comorbidities in this specific population using the validated YLD parameter. We aimed to examine the impact of comorbidities on a homogenous cohort of men with over 20 years of follow-up (FU), using YLD parameter. METHODS: Complete clinical and sociodemographic data from 451 white-European non-Finnish primary infertile men assessed at a single tertiary referral centre were analysed. Comorbidities were scored using Charlson Comorbidity Index (CCI). Annual FU was done until 2023 collecting every de-novo comorbidity. For each one, disability weights (DW) were assigned based on data from the 2019 Global Burden of Disease Study (GBD 2019). We calculated YLD for each patient, taking into account their baseline infertility status and the specific comorbidities which emerged over time. Additionally, we classified the cohort into two groups based on semen parameters: normozoospermia vs. oligo-/azoospermia. To obtain the overall comorbidity burden, we calculated the mean YLD for the entire cohort. Subsequently, we compared the mean YLD of normozoospermia vs. oligo-/azoospermia groups to assess differences in comorbidities impact. RESULTS: Overall, the median IQR age and FU were 49 (45-54) years and 114 (75-152) months, respectively. At baseline, 410 (91.1%) patients had no comorbidities as per CCI. During the FU time frame, 141 (31.3%) patients developed significant health-related comorbidities according to the GBD 2019 study. This occurrence significantly impacted the disease burden, thereby affecting the YLD. Of these, 73 (16.2%) presented cardiovascular health issues, with hypertension being the most prevalent, while 39 (8.7%) exhibited endocrine-metabolic concerns, predominantly represented by dyslipidaemia and diabetes mellitus, and 13 (2.9%) had cancer. Overall, 236 (52.3%) men depicted semen parameters suggestive of normozoospermia, 193 (42.7%) for oligozoospermia, and 21 (4.6) for non-obstructive azoospermia. The mean YLD score for the entire cohort was 0.35 (SD 1.26); when grouped into normozoospermia vs. oligo-/azoospermia, their mean YLD scores were 0.32 (SD 1.17) and 0.38 (SD 1.35), respectively. CONCLUSIONS: The mean YLD score for the entire cohort was 0.35 apparently showing a modest diseases' burden among infertile men. Overall, patients with worse semen parameters depicted higher YLD, meaning they have a higher disease burden as compared with men with normozoospermia at baseline. These findings carry significant public health implications by emphasizing the importance of recognizing infertility as a potential marker for broader health concerns. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e216 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Fausto Negri More articles by this author Edoardo Pozzi More articles by this author Alessandro Bertini More articles by this author Massimiliano Raffo More articles by this author Federico Belladelli More articles by this author Christian Corsini More articles by this author Francesco Cattafi More articles by this author Marco Oddo More articles by this author Marco Malvestiti More articles by this author Luca Boeri More articles by this author Giuseppe Fallara More articles by this author Eugenio Ventimiglia More articles by this author Paolo Capogrosso More articles by this author Federico Dehò More articles by this author Alessia d'Arma More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement PDF downloadLoading ...