Pd37-08 Long-Term Comorbidity Trends Among Men With Primary Infertility: Findings From a Long Term Comprehensive Longitudinal Study

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD37)1 May 2024PD37-08 LONG-TERM COMORBIDITY TRENDS AMONG MEN WITH PRIMARY INFERTILITY: FINDINGS FROM A LONG TERM COMPREHENSIVE LONGITUDINAL STUDY Edoardo Pozzi, Alessandro Bertini, Massimiliano Raffo, Fausto Negri, Federico Belladelli, Christian Corsini, Francesco Cattafi, Marco Malvestiti, Luigi Candela, Giuseppe Fallara, Eugenio Ventimiglia, Luca Boeri, Paolo Capogrosso, Federico Dehò, Alessia d'Arma, Francesco Montorsi, and Andrea Salonia Edoardo PozziEdoardo Pozzi , Alessandro BertiniAlessandro Bertini , Massimiliano RaffoMassimiliano Raffo , Fausto NegriFausto Negri , Federico BelladelliFederico Belladelli , Christian CorsiniChristian Corsini , Francesco CattafiFrancesco Cattafi , Marco MalvestitiMarco Malvestiti , Luigi CandelaLuigi Candela , Giuseppe FallaraGiuseppe Fallara , Eugenio VentimigliaEugenio Ventimiglia , Luca BoeriLuca Boeri , Paolo CapogrossoPaolo Capogrosso , Federico DehòFederico Dehò , Alessia d'ArmaAlessia d'Arma , Francesco MontorsiFrancesco Montorsi , and Andrea SaloniaAndrea Salonia View All Author Informationhttps://doi.org/10.1097/01.JU.0001009464.98066.03.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: A link between Male Factor Infertility and men's health decline has been clinically shown, but long-term data and correlation between comorbidities and sperm concentration remain unclear. We aimed to investigate the development of comorbidities in a cohort of men seeking medical help for primary infertility over a 20-year follow-up (FU) period. METHODS: Data from 451 men from 2003-2018 were analyzed. Comorbidities were scored using Charlson Comorbidity Index (CCI), with annual FU until 2023. Patients underwent serum hormones and semen analysis. Based on semen parameters, the cohort was split into normozoospermia (NZ) and oligozoospermia (OZ)/non-obstructive azoospermia (NOA) groups. Descriptive statistics detailed group differences. Multivariate cox regression tested if semen concentration correlated with CCI-based health status decline. Kaplan-Meier analysis displayed the likelihood of health status worsening based on semen concentration. RESULTS: Median (IQR) FU and age were 114 (75-152) months and 37 (34-41) years, respectively. At baseline, 410 (91.1%) patients had no comorbidities, which decreased to 309 (68.7%) at the last FU. Median (IQR) sperm concentration, BMI and total testosterone (tT) were 16.6 (4.3-41.5) mln/mL, 24.7 (23.2-26.8) kg/m2, and 4.7 (3.5-5.8) ng/mL, respectively. Of all, 236 (52.4%) patients had NZ, while 193 (42.9%) and 21 (4.6%) had OZ and NOA, respectively. When comparing men with NZ to those with OZ/NOA, the former were younger (36 vs. 38 yrs), had higher mean testicular volume (Prader 15 vs. 18), lower baseline FSH (3.8 vs. 8.14 mIU/mL) and tT (4.3 vs. 4.9 ng/mL), all p<0.05. Both groups had similar baseline comorbidities. At multivariate cox regression analysis, lower sperm concentration was identified as a predictor of health status worsening (HR: 1.48, 95%CI: 1.02-2.15, p=0.03) after adjusting for baseline CCI, BMI, age and tT. Kaplan-Meier estimates of CCI decrease over time for OZ/NOA men were 11.2%, 22.3%, and 23% at 5, 10, and 15 years, respectively (Figure 1). CONCLUSIONS: Up to 25% of infertile men developed at least 1 impacting comorbid condition in a relatively short time frame. The lower sperm concentration at baseline, the higher probability of health decline over time, thus supporting the need for tailored secondary prevention strategies. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e802 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Edoardo Pozzi More articles by this author Alessandro Bertini More articles by this author Massimiliano Raffo More articles by this author Fausto Negri More articles by this author Federico Belladelli More articles by this author Christian Corsini More articles by this author Francesco Cattafi More articles by this author Marco Malvestiti More articles by this author Luigi Candela More articles by this author Giuseppe Fallara More articles by this author Eugenio Ventimiglia More articles by this author Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Federico Dehò More articles by this author Alessia d'Arma More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement PDF downloadLoading ...