April 15, 2024Open Access

Supplementary Figure S4 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

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A B7-H4-targeting antibody-drug conjugate demonstrates potent antitumor activity in xenograft models, overcoming both PARP inhibitor and platinum resistance in expressed tumors.
Evaluation across patient-derived xenograft models confirms therapeutic efficacy in resistant breast cancer, providing statistical summaries of tumor regression under treatment.
Highlights B7-H4-ADC as a promising strategy for drug-resistant neoplasms, though findings remain restricted to xenograft mouse models requiring further validation.

Implication

Preclinical evaluation demonstrates antitumor activity of a B7-H4-targeting antibody-drug conjugate in resistant breast cancer models, suggesting therapeutic promise against refractory tumors.

Abstract

Statistical summary of B7-H4-ADC activity in xenograft models and activity in breast cancer PDX models.

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Cite This Study

Gitto et al. (2024) studied this question.

synapsesocial.com/papers/68e6f2a2b6db64358766d0eb https://doi.org/10.1158/1078-0432.25603632.v1

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Implication

Preclinical evaluation demonstrates antitumor activity of a B7-H4-targeting antibody-drug conjugate in resistant breast cancer models, suggesting therapeutic promise against refractory tumors.

Abstract

Statistical summary of B7-H4-ADC activity in xenograft models and activity in breast cancer PDX models.

Supplementary Figure S4 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S4 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Key Points

Implication

Abstract

Discussion

Cite This Study

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