Figure 2 from Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging

Distinct intermodel heterogeneity in PET imaging signatures. A, In the experimental imaging protocol, five colon cancer organoid models and four PET tracers were used to determine imaging signatures. Details of all mice used in these studies are presented in Supplementary Table S1. B, Representative transverse PET images from each model and tracer. The [¹⁸F]FDG PET/MR images of the KPN subcutaneous model are reproduced again in Figs. 4B and D and 5B for comparison against other tumors at different sites and stages. C, Imaging signature heatmap showing mean tracer uptake, models with highest tracer update highlighted with black outline (representation of the data matrix analyzed with two-way ANOVA). D, Correlation matrix of each tracer uptake based on Pearson correlation coefficient. E, Heatmap illustrating correlation of PET tracer uptake with gene expression in the Molecular Signatures Database (MSigDB) hallmark dataset, sorted by hierarchal clustering. (A, Created with BioRender.com.)