Opportunistic double vital staining screening can lead to early oral squamous cell carcinoma diagnosis!

• Oral squamous cell carcinoma is a global health concern associated with significant morbidity and mortality owing to delays in diagnosis. • Early detection of oral potentially malignant disorders and oral squamous cell carcinoma can help improve the survival rates and quality of life. • Opportunistic oral cancer screening on high-risk individuals using simple, easy-to-use, patient-friendly, cost-effective, and effective tools is the need of the hour. • Double staining procedure using Methylene Blue and Lugol's Iodine can be tried in mass oral cancer screening programs by primary health care providing paramedics and help reduce the oral cancer burden.