Neurologic Autoimmunity in the Immunodeficient: A Case of Neuromyelitis Optica Developing in an Individual with Common Variable Immunodeficiency (P7-14.002)

Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing CNS autoimmune disorder most commonly characterized by longitudinally extensive transverse myelitis (LETM) and/or optic neuritis (ON). Common variable immunodeficiency (CVID) is the most common clinically significant primary immunodeficiency, characterized by immune dysregulation and decreased immunoglobulin production. Autoimmunity is common in CVID, however neurologic autoimmunity is exceedingly rare and co-occurrence with NMOSD has not been previously described.