April 8, 2024Nature CommunicationsOpen Access

Immunoregulatory role of the gut microbiota in inflammatory depression

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Recipient mice display depressive behaviors and elevated peripheral inflammation following fecal microbiota transplantation from patients with inflammatory depression.
Observational trial data ChiCTR1900025175 reveals higher Bacteroides, lower Clostridium, and altered butanoate metabolism in patient stool and intestinal mucosa samples.
Highlights therapeutic potential of Clostridium butyricum to reduce systemic inflammatory factors and depressive behaviors—mouse model; further clinical validation needed.

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Implication

Observational trial reveals gut microbiota dysbiosis in patients with inflammatory depression, suggesting gut-derived inflammation contributes to neuroinflammatory pathology.

Cite This Study

Liu et al. (2024) studied this question.

synapsesocial.com/papers/68e6febab6db6435876792e4 https://doi.org/10.1038/s41467-024-47273-w

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Implication

Observational trial reveals gut microbiota dysbiosis in patients with inflammatory depression, suggesting gut-derived inflammation contributes to neuroinflammatory pathology.

Immunoregulatory role of the gut microbiota in inflammatory depression

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Discussion

Implication

Cite This Study

Immunoregulatory role of the gut microbiota in inflammatory depression

Key Points

Discussion

Implication

Cite This Study

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