Mechanistic study reveals that interleukin-6 promotes visceral adipose tissue accumulation during aging, indicating that lipolysis inhibition drives obesity.
Age-related visceral obesity could contribute to the development of cardiometabolic complications. The pathogenesis of visceral fat mass accumulation during the aging process remains complex and largely unknown. Interleukin-6 (IL-6) has emerged as one of the prominent inflammaging markers which are elevated in circulation during aging. However, the precise role of IL-6 in regulating age-related visceral adipose tissue accumulation remains uncertain.
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Zhang et al. (2024) studied this question.
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