• One of the hardest malignancies to monitor and treat is Oral Cancer, which has recurrent metastases and local lymph node invasion. • Nrf2 suppression decreases Nrf2 copies and inhibits migration in OSCC cells by altering Keap1/Nrf2/HO-1, NALP3 inflammasome, and EMT protein expression. • On the other hand, in OSCC, Nrf2 enhanced glycolysis and glutathione synthesis, making it radioresistant. • Both stimulation and inhibition of NRF2 exhibit anticancer action in oral via targeting altered pathways. • The identification, development, and production of NRF2 inhibitors are crucial and complex endeavours in the pursuit of effective oral cancer treatment.
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Renu et al. (2024) studied this question.
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