April 5, 2024Frontiers in Pain ResearchOpen Access

Sustained release local anesthetics for pain management: relevance and formulation approaches

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Authors

MGMelese GetachewDebre Markos University HTHana TesfayeMattu University WBWubetu Yihunie BelayDebre Markos University

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Implication

Review demonstrates formulation approaches for sustained-release local anesthetics in acute and chronic pain, highlighting delivery systems that prolong localized analgesia.

Key Points

Sustained-release local anesthetics prolong regional analgesia from a single administration, eliminating the need for repeated injections or opioid adjuvants in pain management.
Review of advanced drug delivery systems highlights lipid-based nanoparticles, liposomal formulations, thermo-responsive nanogels, and bio-adhesive films for localized relief.
Highlights indicate that extensive safety studies and precise evaluation of release kinetics are required to validate sustained-release formulations before clinical deployment.

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Getachew et al. (2024) studied this question.

synapsesocial.com/papers/68e70328b6db64358767d5e8 https://doi.org/10.3389/fpain.2024.1383461

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Implication

Review demonstrates formulation approaches for sustained-release local anesthetics in acute and chronic pain, highlighting delivery systems that prolong localized analgesia.

Sustained release local anesthetics for pain management: relevance and formulation approaches

Discussion

Member takes

Implication

Key Points

Cite This Study

Sustained release local anesthetics for pain management: relevance and formulation approaches

Discussion

Member takes

Implication

Key Points

Cite This Study

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