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July 31, 2026Anesthesia and Pain MedicineOpen Access

Sustained-release local anesthetics: advances in drug delivery systems for prolonged postoperative analgesia

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Authors

SOSeok Kyeong OhSHSang Hyun HongJSJung‐Woo Shim

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Overview

Randomized trial demonstrates prolonged analgesia with sustained-release local anesthetics, suggesting improved postoperative recovery.

Key Points

  • The aim is to evaluate new drug delivery systems for sustained-release local anesthetics to improve postoperative pain management.
  • Evaluated various sustained-release formulations, including liposomal, polymer-based, and hydrogel carriers.
  • Discussed mechanisms of sustained drug release and their impact on postoperative analgesia.
  • Assessed clinical implications and challenges of adoption in practice.
  • Sustained-release formulations significantly prolong analgesia compared to conventional local anesthetics, indicating improved pain management.
  • Liposomal bupivacaine effectively releases anesthetic over extended periods, enhancing patient comfort post-surgery.
  • Challenges remain, including cost and variability in release kinetics, affecting clinical implementation.

Cite This Study

Oh et al. (2026) studied this question.

synapsesocial.com/papers/6a6c46f4747664a1aa73bee8https://doi.org/10.17085/apm.26668
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sustained release local anesthetics for pain management: relevance and formulation approaches2024 · 18 citations
  2. 2Molecularly Engineered Controlled Release Systems for Local Anesthetics in Precise Pain Management2025
  3. 3Building a Bridge from Material Design to Clinical Translation of Sustained-Release Local Anesthetic Systems2026
  4. 4New long-acting local anesthetics: recent formulations and safety2026
  5. 5Innovations in Postoperative Pain Management: Continuous Infusion of Local Anesthetics2007 · 21 citations