April 5, 2024Open Access

Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male Mice

View Full Paper

Ask AI

Bookmark

Authors

IRIlaria RussoColumbia University WDWen DunColumbia University Irving Medical Center SMSwasti MehtaMetroHealth

Discussion

Member takes

Implication

Preclinical study reveals extracellular matrix instability and inflammation drive right ventricular failure in male mice, highlighting mechanisms underlying sex-specific cardiac remodeling.

Key Points

Right ventricular dysfunction and failure in male mice are driven by extracellular matrix instability, whereas female mice maintain matrix stability.
Following 9 weeks of pulmonary artery banding, male mice exhibited severe right ventricular failure with recruitment and activation of inflammatory macrophages.
Assessment using cardiac MRI and pressure-volume loop recordings identified sex-specific remodeling—a mouse model finding requiring further preclinical validation.

Cite This Study

Russo et al. (2024) studied this question.

synapsesocial.com/papers/68e70336b6db64358767da68 https://doi.org/10.1101/2024.04.03.588013

View Full Paper

Ask AI

Bookmark

April 5, 2024Open Access

Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male Mice

View Full Paper

Ask AI

Bookmark

Authors

IRIlaria RussoColumbia University WDWen DunColumbia University Irving Medical Center SMSwasti MehtaMetroHealth

Discussion

Member takes

Implication

Preclinical study reveals extracellular matrix instability and inflammation drive right ventricular failure in male mice, highlighting mechanisms underlying sex-specific cardiac remodeling.

Key Points

Right ventricular dysfunction and failure in male mice are driven by extracellular matrix instability, whereas female mice maintain matrix stability.
Following 9 weeks of pulmonary artery banding, male mice exhibited severe right ventricular failure with recruitment and activation of inflammatory macrophages.
Assessment using cardiac MRI and pressure-volume loop recordings identified sex-specific remodeling—a mouse model finding requiring further preclinical validation.

Cite This Study

Russo et al. (2024) studied this question.

synapsesocial.com/papers/68e70336b6db64358767da68 https://doi.org/10.1101/2024.04.03.588013

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark