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September 16, 2025

The effect of Microvascular Remodeling on Fluid Dynamics in the Pressure Overloaded Right Ventricle.

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Authors

IEIlham EssafriKIKenzo IchimuraDIDunbar Ivy

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Overview

Analysis reveals microvascular changes affecting hemodynamics in right ventricle under pressure overload, highlighting sex-based differences.

Key Points

  • Microvascular remodeling in right ventricular failure reduces hemodynamic resistance and wall shear stress, indicating adaptive changes.
  • Mice post-pulmonary artery banding showed significant alterations in microvascular structure compared to SHAM controls, highlighting the impact of remodel.
  • Advanced 3D imaging and computational fluid dynamics were employed to analyze hemodynamic parameters in the right ventricle.
  • Sex-specific variations were noted in hemodynamic resistance, with significant implications for understanding cardiovascular responses.

Cite This Study

Essafri et al. (2025) studied this question.

synapsesocial.com/papers/68c93fee01120bef803bb18dhttps://doi.org/10.1152/ajpheart.00147.2025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 13D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension2024 · 5 citations
  2. 2Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male Mice2024 · 3 citations
  3. 3Pulmonary Arterial Hypertension Induces Sex-Specific Right Ventricular Transcriptomic Remodeling2026
  4. 4The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload2020 · 14 citations
  5. 5D106-23 Sex-Specific Right Ventricular Adaptation to Exercise and Pressure Overload: Roles of Macrophages in Hypertrophy and Fibrosis2026