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April 5, 2024European journal of medical researchOpen Access

Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis

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Authors

YWYizhi WangYKYang KongQYQifan Yang

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Overview

Retrospective multi-database analysis reveals elevated FNDC3B expression correlates with poor survival in pancreatic cancer, suggesting its role as a potential prognostic biomarker.

Key Points

  • Elevated FNDC3B expression occurs across pancreatic cancer tissues and actively enhances malignant cell proliferation, migration, and invasion in preliminary assays.
  • Kaplan-Meier analysis links high FNDC3B expression to significantly reduced overall survival, disease-specific survival, and progression-free intervals in patients.
  • Highlights FNDC3B as a prospective prognostic biomarker modulating immune infiltration and integrin signaling, though cell models warrant further experimental validation.

Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e7044fb6db64358767db29https://doi.org/10.1186/s40001-024-01823-6
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Also Consider

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  1. 1FNDC1 is closely related to poor prognosis and immune cell infiltration in gastric cancer2026 · 1 citations
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  4. 4BNIP3 + cancer-associated fibroblasts and their associated genes are accelerators of pancreatic cancer2024
  5. 5Single-cell Sequencing Analysis Reveals Cell Subtypes With High Expression of Coagulation Factor 3 and Their Possible Roles in Pancreatic Ductal Adenocarcinoma2025 · 1 citations