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The study aims to explore FNDC1's impact on gastric cancer progression and its relationship with immune cell infiltration.

April 17, 2026Scientific ReportsOpen Access

FNDC1 is closely related to poor prognosis and immune cell infiltration in gastric cancer

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Investigates FNDC1's role in immune cell infiltration and prognosis in gastric cancer, suggesting its importance for patient outcomes.

The study aims to explore FNDC1's impact on gastric cancer progression and its relationship with immune cell infiltration.
Analyzed FNDC1 expression profiles using TCGA, GTEx, and GEO databases.
Conducted quantitative real-time PCR and immunohistochemistry for validation.
Performed gene set enrichment analysis to identify differentially expressed genes.
Utilized Cox regression and Kaplan-Meier analyses for prognostic significance.
Conducted in vitro assays to evaluate FNDC1's role in cancer cell migration and invasion.
FNDC1 expression significantly increased in gastric cancer tissues compared to normal samples (P < 0.001).
Identified 359 differentially expressed genes linked to extracellular matrix signaling pathways.
Positive correlations found between FNDC1 and infiltration of macrophages and NK cells (r = 0.564, P < 0.001; r = 0.566, P < 0.001).
FNDC1 expression correlated with poorer clinicopathological factors and overall survival (P < 0.05).
Developed a nomogram predicting 1-, 3-, and 5-year overall survival probabilities with a C-index of 0.714.

Zhang et al. (2026) studied this question.

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