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March 13, 2026The FASEB JournalOpen Access

FNDC1 Competitively Binds Gβ2 to Suppress the β‐Catenin–Destruction Complex and Promote Gastric Cancer Malignancy

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Authors

WGWenyu GaoFujian Medical UniversityHCHao ChenFujian Medical UniversityFLFei LinFujian Medical University

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Overview

Multi-omics analyze FNDC1's role in gastric cancer, revealing it promotes malignancy via Gβ2 and Wnt signaling.

Key Points

  • This research aims to understand how FNDC1 contributes to gastric cancer progression and its underlying mechanisms.
  • Multi-omics analysis of TCGA and GEO datasets to assess FNDC1 expression.
  • In vitro experiments on cell proliferation and invasion, along with EMT marker assessment.
  • In vivo xenograft studies to investigate FNDC1 function.
  • Molecular assays including Co-IP, WB, and ChIP to explore mechanistic pathways.
  • FNDC1 is significantly upregulated in gastric cancer and correlates with poor prognosis.
  • Knockdown of FNDC1 leads to decreased cell proliferation, invasion, and metastasis.
  • FNDC1 binds Gβ2, disrupting Gβγ-Dvl1 interaction, preventing Dvl1 degradation.
  • This results in increased Axin1 ubiquitination and destabilization of the β-catenin-destruction complex.

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69b3ac6002a1e69014ccdffehttps://doi.org/10.1096/fj.202503587r
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of FNDC1 and Gβ2 in suppression of the β-catenin destruction complex and promotion of gastric cancer malignancy.2026
  2. 2FNDC1 is closely related to poor prognosis and immune cell infiltration in gastric cancer2026 · 1 citations
  3. 3Investigation of the pan-cancer property of FNDC1 and its molecular mechanism to promote lung adenocarcinoma metastasis2024 · 2 citations
  4. 4A novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc2024 · 12 citations
  5. 5DKC1 aggravates gastric cancer cell migration and invasion through up-regulating the expression of TNFAIP62024 · 9 citations