April 4, 2024Frontiers in MicrobiologyOpen Access

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

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Authors

FHFurong HuangHunan Normal University BLBo LyuZhanjiang Experimental Station FXFanci XieGuangzhou University of Chinese Medicine

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Implication

Comparative analysis reveals distinct gut microbial shifts across fatty liver and steatohepatitis stages, highlighting potential diagnostic biomarkers.

Key Points

Intestinal microbiota diversity decreases significantly during the progression of non-alcoholic fatty liver disease, accompanied by high levels of Fusobacteria (p < 0.05).
Using 16S rRNA sequencing and random forest models across 182 participants, Prevotella dropped in NAFL (AUC 0.738), while Megamonas and Fusobacterium rose in NASH (AUC 0.769).
KEGG pathway analysis highlights disrupted glucose metabolism and impaired flavonoid biosynthesis, which may facilitate novel therapeutic targets in non-alcoholic steatohepatitis.

Cite This Study

Huang et al. (2024) studied this question.

synapsesocial.com/papers/68e7055ab6db64358767fac5 https://doi.org/10.3389/fmicb.2024.1366744

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Implication

Comparative analysis reveals distinct gut microbial shifts across fatty liver and steatohepatitis stages, highlighting potential diagnostic biomarkers.

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

Discussion

Member takes

Implication

Key Points

Cite This Study

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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