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Bloodstream infection (BSI) is a prevalent complication with a high fatality rate in cancer patients. Over time and in different countries, there are noticeable changing trends in the epidemiology of BSI. With this context, our goal was to investigate the antibiogram and distribution of bacterial pathogens causing BSI in central Indian cancer patients. This single-center retrospective observational study was conducted in an Indian cancer hospital that offers tertiary care. Patients with solid organ and haematological cancers in both adults and children who had blood cultures sent to the microbiology laboratory were all included. In accordance with the recommendations of the Clinical and Laboratory Standards Institute (CLSI), blood cultures were processed using the BacT/ALERT 3D system (BioMerieux, France) and identification of bacteria to species level and antimicrobial susceptibility (AST) was carried out using the Vitek 2 compact system (BioMerieux, France). Electronic medical records and microbiology lab records were used to retrieve the demographic and microbiological data. Microsoft Excel (Microsoft Excel, RRID: SCR₀16137) was used to enter and tabulate the data, while SPSS (RRID: SCR₀02865) was used to conduct the statistical analysis. Hemato-lymphoid cancer had a higher culture positive rate than solid organ cancer. In cancer patients, BSI was more frequently caused by gram-negative bacteria.
Choudhari et al. (Thu,) studied this question.