April 2, 2024ChemBioChem

Bile Salt Hydrolase Activity‐Based Probes for Monitoring Gut Microbial Bile Acid Metabolism

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Authors

LHLin HanCornell University RXRaymond XuCornell University ACAmanda N. ConwellCornell University

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Implication

Preclinical evaluation reveals rhythmic bile salt hydrolase activity and substrate preference in gut bacteria, indicating circadian regulation of microbial bile acid metabolism.

Key Points

Gut microbiota-associated bile salt hydrolase activity and substrate preference exhibit diurnal rhythmicity, which appears driven by host feeding patterns in murine models.
Development of covalent activity-based probes enables functional profiling of gut anaerobic bacteria, capturing specific substrate specificity from mouse and human microbiomes.
Profiling microbial secondary bile acid pathways may enable assessment of circadian-regulated disease states; mouse model requires further validation in clinical cohorts.

Cite This Study

Han et al. (2024) studied this question.

synapsesocial.com/papers/68e70b3ab6db643587684cc8 https://doi.org/10.1002/cbic.202300821

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Implication

Preclinical evaluation reveals rhythmic bile salt hydrolase activity and substrate preference in gut bacteria, indicating circadian regulation of microbial bile acid metabolism.

Bile Salt Hydrolase Activity‐Based Probes for Monitoring Gut Microbial Bile Acid Metabolism

Discussion

Member takes

Implication

Key Points

Cite This Study

Bile Salt Hydrolase Activity‐Based Probes for Monitoring Gut Microbial Bile Acid Metabolism

Discussion

Member takes

Implication

Key Points

Cite This Study

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